Keynote Speaker Joseph Loscalzo

Описание: Speaker: Joseph Loscalzo, MD, PhD, Samuel A. Levine Professor of Medicine, Hersey Distinguished Professor of the Theory and Practice of Medicine, Harvard Medical School, Physician-in-Chief Emeritus, Brigham and Women’s Hospital

Talk Title: “Challenges in Contemporary Drug Discovery”

Abstract: Drug discovery is a complicated semi-empirical process that fails ~90% of the time. The reasons for this high failure rate are multiple and include the presence of competing targets within a cell or organism; the existence of multiple conformations of any single target protein; significant inconsistencies in binding or kinetic constants in cell-free vs. cellular systems; and failure to consider the effect of a drug on its target(s) within the complex cellular protein-protein interaction network and its consequences for phenotype. In this presentation, I will discuss the evolving landscape of computational approaches used to identify disease determinants and drug targets, including network- and AI-based approaches and quantum-inspired strategies; experimental approaches to characterizing the dynamic interactions of drugs and their targets in real time in single cells; and efficient single-cell strategies for assessing combinations of drugs. These principles will be illustrated with examples from specific diseases. The strategies presented will ultimately contribute to and guide the ongoing evolution of precision medicine.