Gastrin Signaling Promotes Gastric Repair and Prevents Dysplasia
Автор: Gastroenterology at BMJ
Загружено: 2026-02-13
Просмотров: 19
Описание:
To cite: Zheng B, Kobayashi H, Tu R, et al. Gastrin-dependent expansion of Cck2r+ corpus progenitors accelerates ulcer healing and inhibits gastric dysplasia. Gut 2026;75:265-277.
Read the full article here: https://doi.org/10.1136/gutjnl-2025-3...
Background: The cholecystokinin-2/gastrin receptor (Cck2r) is expressed in corpus isthmus progenitor, enterochromaffin-like and parietal cells, regulating acid secretion and cell turnover. However, the role of gastrin on Cck2r progenitors during mucosal regeneration remains unexplored.
Conclusion: We report a novel role for G-cell-derived gastrin in ulcer healing. Hypogastrinaemia is a risk factor for poor ulcer healing, corpus atrophy and potentially cancer, while physiological gastrin responses are protective. PPI-induced hypergastrinaemia plays a key role in ulcer healing, and gastrin signalling may prevent gastric preneoplasia.
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