Using Moran's I to identify spatially variable genes in spatial transcriptomics data

Описание: In this lecture, we will learn how to analyze spatial transcriptomics data to distinguish spatially variable genes that exhibit coordinated spatial variation, from genes that may be highly variable but in a less spatially coordinated manner using the Moran's I statistic.

Key moments:
Main Lecture on Moran's I as applied to spatial transcriptomics data:    • Using Moran's I to identify spatially vari...  
Practice:    • Using Moran's I to identify spatially vari...  
Evaluating the statistical significance of Moran's I under spatial randomness null model:    • Using Moran's I to identify spatially vari...  
Coding demo using MERINGUE to apply Moran's I:    • Using Moran's I to identify spatially vari...  
Alternative ways of encoding adjacency relationships:    • Using Moran's I to identify spatially vari...  

Additional relevant coding tutorials and resources:
Additional packages for running Moran's I in R: https://jef.works/blog/2024/08/29/the...
Combining MERINGUE with SEraster for faster analysis of spatially variable genes: https://jef.works/blog/2024/03/24/spa...
MERINGUE paper: https://jef.works/assets/papers/Mille...
MERINGUE website with additional tutorials: https://jef.works/MERINGUE/

Music by Christoph Scholl: https://pixabay.com/users/tuesdaynigh...