Preparation of Pyridines, Part 8: Chemistry of Pyridine-N-oxides

Описание: This video is about the preparation and transformations of pyridine-N-oxides. These compounds are easy to prepare from pyridines and allow a number of chemical transformations that cannot be performed with the parent pyridines. I'll show you examples of the preparation, reduction, and various transformations of pyridine-N-oxides.
Further examples (patents are available at https://worldwide.espacenet.com/):
Reviews
Chem. Rev. 2022, 122, 2429-2486; Eur. J. Org. Chem. 2021, 357-373;
Chem. Rev. 2012, 112, 2642-2713;

Preparation
Tetrahedron Lett. 2014, 55, 2513-2516;
Syn. Comm. 2004, 34, 247-253; J. Mol. Catal. A 2002, 186, 109-120;
Tetrahedron 1961, 14, 151-160; Org. Syn. 1953, 33, 79;

Deoxygenation
Catal. Sci. Tech. 2021, 11, 312-318; Eur. J. Org. Chem. 2020, 1853-1865; Synlett 2013, 24, 2695-2700;
Bull. Korean Chem. Soc. 2013, 34, 359-360; Chem. Eur. J. 2013, 19, 17456-17463; Tetrahedron Lett. 2010, 51, 5690-5693; 2009, 50, 949-952; Synlett 2008, 2579-2582; Tetrahedron 2007, 63, 126-130; Synlett 2005, 1389-1392; Org. Lett. 2000, 2, 3525-3526; Gazz. Chim. Ital. 1990, 120, 67-68; Pol. J. Chem. 1985, 59, 627-629;

Halogenation
Org. Lett. 2015, 17, 2948-2951; Org. Proc. Res. Dev. 2003, 7, 38-43; Org. Syn. 1957, 37, 12;

Alkylation, Arylation
Org. Lett. 2021, 23, 6977-6981; Org. Lett. 2018, 20, 3487-3490; Eur. J. Org. Chem. 2018, 1559-1566;
Adv. Syn. Catal. 2018, 360, 905-910; Org. Lett. 2016, 18, 6228-6231; 2015, 17, 414-417;
Org. Biomol. Chem. 2015, 13, 11184-11188; Org. Lett. 2014, 16, 3336-3339;
J. Org. Chem. 2013, 78, 2720-2725; Org. Biomol. Chem. 2013, 11, 4438-4441; Org. Lett. 2013, 15, 54-57; Synlett 2012, 23, 938-942; Org. Lett. 2011, 13, 6102-6105; Org. Syn. 2011, 88, 22;
Chem. Comm. 2010, 46, 3384-3386; J. Am. Chem. Soc. 2008, 130, 9254-9256;
J. Org. Chem. 2006, 71, 4689-4691; J. Am. Chem. Soc. 2005, 127, 18020-18021;
Syn. Comm. 1989, 19, 317-325; J. Org. Chem. 1972, 37, 1690-1696;

Acylation, Reaction with Anhydrides
Adv. Syn. Catal. 2021, 363, 2806-2812; Tetrahedron Lett. 2020, 61, 152401;
Org. Lett. 2019, 21, 5321-5325; J. Org. Chem. 2018, 83, 12420-12431;
RSC Advances 2014, 4, 31685-31688; J. Am. Chem. Soc. 2012, 134, 3683-3686;
Syn. Comm. 2008, 38, 1725-1736; Heterocycles 1987, 26, 1263-1270;
Chem. Pharm. Bull. 1987, 35, 4093-4100; J. Org. Chem. 1960, 25, 1716-1718;

Cyanation
J. Heterocyclic Chem. 2011, 48, 961-964; J. Am. Chem. Soc. 2008, 130, 2414-2415;

Amination
J. Org. Chem. 2014, 79, 2274-2280; Org. Lett. 2013, 15, 168-171;
Org. Lett. 2010, 12, 5254-5257; J. Org. Chem. 2007, 72, 4554-4557;
Org. Lett. 2002, 4, 3127-3129.