How to Make Your Brain Ageless: Prevent Cognitive Decline & Supercharge Your Mind | Dale Bredesen

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The messaging that we should pretty much live our lives however we choose, and then,
when we begin to have problems, like cognitive issues, there will be a magic treatment
that will help pull us through, is unfortunate, myopic, unrealistic, and frankly threatening.
The reality is that the choices we make, each and every day, are profoundly influential
in terms of charting our brain’s destiny, and this is especially important in that there is
no clearcut pharmaceutical agent that can help us once our brains begin to fail. That
said, I was delighted to spend time on our podcast today with Dr. Dale Bredesen, whose
new book, The Ageless Brain, is an incredible resource for actions that we can be
taking each and every day to stave off diseases like Alzheimer’s, and even enhance
how our brains are working right now.

If you’ve followed his work, you know he’s been at the forefront of Alzheimer’s research, pioneering a comprehensive approach to preventing and even reversing cognitive decline. The Ageless Brain, takes this mission a step further, offering a powerful blueprint for not only sharpening and protecting your mind but also making it more resilient to neurodegenerative diseases. In The Ageless Brain, Dr. Bredesen distills decades of research into actionable steps that anyone can take to enhance their brain health.

He delves into the key lifestyle factors—nutrition, sleep, exercise, stress management, and targetedsupplementation—that influence cognitive performance and long-term resilience. What’s particularly exciting about this book is its focus on a proactive, personalized approach. Instead of waiting for signs of cognitive decline, Dr. Bredesen shows us how to build a brain that resists aging from the start.

Today, we’re going to unpack some of the most impactful strategies from The Ageless
Brain, discuss the latest breakthroughs in neuroscience, and explore how we can all
take charge of our cognitive destiny. If you’ve ever wondered what it takes to optimize
your brain for a lifetime of clarity and vitality, you won’t want to miss this conversation.
Dale Bredesen, MD, is an internationally recognized neurologist with specialty expertise
in the mechanisms of neurodegenerative diseases. He is the senior director of Precision
Brain Health at Pacific Neuroscience Institute® and the Chief Scientific Officer at Apollo
Health.

Guided by his philosophy and belief that Alzheimer’s disease is not just preventable but
reversible, Dr. Bredesen’s innovative research has helped explain the physical
mechanism behind the erosion of memory seen in Alzheimer’s disease. His decades of
clinical study and neurological research have opened the door to new approaches to
treatment, leading to the ReCODE Protocol™. Also known as the Bredesen Protocol,
this methodology has emerged as a viable attempt to prevent, arrest, and reverse
symptoms of cognitive decline associated with conditions such as Alzheimer’s disease,
dementia, and mild cognitive impairment.


Timestamps:
0:00 Introduction to Guest
2:48 Phase 3 Trial Upcoming
10:11 Alzheimer’s: Different Triggers, Different Outcomes
13:11 Could Brushing Your Teeth Save Your Brain? (Oral Microbiome & Alzheimer’s)
18:45 The 3 Major Players in Brain Health
22:24 How to Make Sure You Never Get Dementia
22:33 Blood Markers for Alzheimer’s: What Your Tests Reveal
28:10 Diabetes and Alzheimer’s: The Hidden Connection
34:18 The #1 Contributor to Cognitive Decline: Insulin Resistance
39:54 How to Match Your Brainspan to Your Lifespan
40:31 Top Supplements for Brain Health
43:15 The Power of Nitric Oxide for Your Brain
48:07 Leaky Gut & Cognitive Decline
54:15 Metformin & Brain Longevity
57:31 Why Do More Men Than Women Get Parkinson’s?
1:05:24 ADHD & Alzheimer’s: The Fruit Fly Discovery ("Alzflymers")

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Dale Bredesen, M.D. is an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease. He is a graduate of Caltech, and received his MD from Duke University Medical Center. His career has included serving as Chief Resident in Neurology at the University of California, San Francisco, and served as a NIH Postdoctoral Fellow. His faculty position included working at UCSF, UCLA, and the University of California, San Diego. He was the director of the Program on Aging at the Burnham Institute. He was the founding President and CEO of the Buck Institute. He has developed a new therapeutic approach to treating Alzheimer's disease. He is the author of The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline.

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