Psychedelic Research at NUDZ and in the Czech Republic

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uniMIND Symposium Prague Replay:

In this presentation, Dr. Tomáš Páleníček — psychiatrist, neuroscientist, and senior researcher at the National Institute of Mental Health (NUDZ), Czech Republic — offers a comprehensive overview of the country’s deep-rooted and evolving legacy in psychedelic research.

From the early experiments of the 1950s and 60s — where thousands of patients underwent psychedelic and psycholytic treatments — to the pioneering work of Stanislav Grof and the transformation of the original Psychiatric Research Institute into today’s NUDZ, the Czech Republic has long been at the forefront of psychedelic science.

Dr. Páleníček traces this journey through decades of preclinical and clinical research: from animal studies with MDMA and psychedelics starting in 2002, to human trials with ketamine and psilocybin for treatment-resistant depression, palliative care, and more. His team’s work integrates advanced neuroimaging with clinical outcomes and phenomenological analysis, bridging subjective experience with neural data.

In addition to research at NUDZ, Dr. Páleníček co-founded Psyon, the Czech Republic’s first psychedelic clinic, where ketamine-assisted psychotherapy is now offered in routine practice. Current projects also include innovative psilocybin trials for cardiovascular health and collaborations focused on accessibility, cost-effectiveness, and destigmatization of psychedelic therapies.

This talk provides a rare and detailed look into how one of Europe’s most active psychedelic research hubs is shaping the future of psychedelic-assisted care — blending tradition, innovation, and clinical rigor.