The Thin Line Between DCLD and ACLF: A Clinical Guide

Описание: ACLF (Acute-on-Chronic Liver Failure) is a distinct clinical syndrome characterized by acute decompensation of chronic liver disease, organ failure, and high short-term mortality. It is critical to differentiate ACLF from Decompensated Chronic Liver Disease (DCLD) because the management and prognosis are vastly different.

In this video, we cover the latest updates on the definition, diagnosis, and management of ACLF. We break down the major differences between the APASL and EASL-CLIF guidelines and explain why the CLIF-C ACLF score is now preferred over MELD for prognostication in these patients.

In this video, you will learn:

The Key Difference: Why DCLD involves ascites/variceal bleeding without organ failure, whereas ACLF is defined by the "Systemic Inflammation Storm" and multi-organ failure.

Diagnosis Criteria: APASL (Jaundice + Coagulopathy) vs. EASL-CLIF (Cirrhosis + Organ Failure).

Scoring Systems: How to calculate and interpret the CLIF-SOFA and CLIF-C ACLF scores.

Management: The "Golden Window" of opportunity, identifying precipitants (infections, alcohol), and the role of G-CSF, albumin, and early Liver Transplant assessment.

This lecture is high-yield for hepatologists, intensivists, and students preparing for NEET SS (Gastroenterology/Hepatology) or MD Medicine exams.

Timestamps: 0:00 - Introduction: Why ACLF is NOT just Decompensation 1:30 - Defining ACLF: APASL vs. EASL-CLIF Criteria 3:45 - Pathophysiology: The Systemic Inflammation Hypothesis 5:00 - Scoring Systems: CLIF-C ACLF vs. MELD vs. AARC 7:15 - Management Protocol: The Golden Window 9:00 - Prognosis & When to List for Transplant

#ACLF #LiverFailure #DCLD #Hepatology #Gastroenterology #LiverTransplant #MedicalEducation #NEETSS #CLIFSOFA #APASL #InternalMedicine #Cirrhosis