Appel Reaction Explained: Mechanism, Stereochemistry & Examples NTA CSIR NET GATE IIT JAM Chemistry

Описание: The Appel reaction, a powerful and often overlooked transformation in organic synthesis that converts alcohols into alkyl halides using triphenylphosphine and halogen sources.

You will learn:

The complete step-by-step mechanism of the Appel reaction

The role of triphenylphosphine (PPh₃) and carbon tetrahalides / iodine

Formation of phosphonium intermediates

Why P=O bond formation is the driving force of the reaction

SN2 vs SN1 pathways in the Appel reaction

Inversion of configuration and racemization

Reactions of primary, secondary, and tertiary alcohols

Important exam-oriented MCQs

Real synthetic examples, including stereospecific transformations

This lecture is ideal for:

BSc / MSc Chemistry students

IIT-JAM, CSIR-NET, GATE, JAM, JEE (Advanced) aspirants

Anyone looking to strengthen their reaction mechanism skills

📌 Key topics covered
Appel reaction mechanism, stereochemistry, SN1 vs SN2, inversion of configuration, phosphonium intermediates, alcohol to alkyl halide conversion, organic synthesis reactions.

🔔 Don’t forget to like, share, and subscribe for more concept-driven organic chemistry lectures.


Appel reaction, Appel reaction mechanism, alcohol to alkyl halide, triphenyl phosphine reaction, SN1 SN2 reactions, stereochemistry organic chemistry, inversion of configuration, organic synthesis reactions, chemistry reaction mechanisms