Metabolic-dysfunction Associated Steatohepatitis | MASH | liver disease animation

Описание: A few selected sequences produced for a recent Medscape CME / ABIM MOC / CE symposium.

The full 2.5- minute animation was developed to be played as a visual aid when the moderator discussed epidemiology and pathogenesis.

Our role: conceptualize and develop a visual science story that provides insight into the pathophysiology of NAFLD, NASH, and MASH -- including the role of fatty acids, insulin resistance, and steatosis, as well as mitochondrial dysfunction, excess ROS production, and the stress put on the endoplasmic reticulum inside ballooning hepatocytes.

In addition, we depicted key attributes of the progression of non-alcoholic steatohepatitis (NASH) including bloated hepatocytes and the fat droplets accumulating inside, displaced cell organelles, lobular inflammation, and the scarring (fibrosis) that occurs as collagen fibers fill the spaces once cell death occurs.

In the last few years, nonalcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and metabolic-dysfunction-associated steatohepatitis have become the most common causes of chronic liver disease worldwide. This epidemic is starting to parallel the epidemics of obesity and type 2 diabetes.

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