Inflammatory bowel disease risk increased by environmental chemicals
Автор: Medical Dialogues
Загружено: 2022-10-20
Просмотров: 55
Описание:
#environmentalmethods #inflammatorydisorders
A new study by investigators from Brigham and Women’s Hospital, leverages
multiple research platforms to systematically identify environmental chemical agents that influence gastrointestinal inflammation. Their findings, published in Nature, identify a common herbicide, propyzamide, that may boost inflammation in the small and large intestine.
The researchers conducted their work by integrating IBD genetics databases with a large Environmental Protection Agency database, ToxCast, which includes biochemical data on consumer, industrial, and agricultural products. They identified chemicals predicted to modulate inflammatory pathways and then used a novel zebrafish IBD model to test these compounds and determine whether they improve, worsen, or did not affect gut inflammation.
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