AntiHelmintic Drugs - Part 1 Introduction and Mazzotti reaction

Описание: Antihelminthic drugs play a crucial role in the treatment and control of parasitic worm infections that affect over 1 billion people worldwide. In this video (Antihelminthic Drugs – Part 1), we provide a clear, clinically focused overview of helminth infections and the key drugs used to treat them.

This lecture begins by explaining what antihelminthic (anthelmintic) drugs are and how they selectively target parasitic worms while sparing the human host. We then classify helminths into their three major groups:

Nematodes (roundworms)

Trematodes (flukes)

Cestodes (tapeworms)

You’ll learn about the global health impact of helminth infections, including malnutrition, anemia, growth impairment, and chronic organ damage—particularly in tropical and subtropical regions. The video also highlights the importance of mass deworming programs and public health strategies.

The second half of the lecture focuses on important antihelminthic drugs, including:

Albendazole / Mebendazole – mechanism of action, spectrum, dosing, side effects, and pregnancy precautions

Pyrantel pamoate – neuromuscular blockade, clinical uses, and safety in children

Ivermectin – drug of choice for strongyloidiasis and onchocerciasis, mechanism, dosing, and the Mazzotti reaction

Thiabendazole – historical use and current topical indications

Special clinical pearls are discussed, such as:

Why ivermectin is preferred in Strongyloides infections

Safety considerations in pregnancy and immunocompromised patients

Recognition and management of the Mazzotti reaction

This video is ideal for:

Medical & pharmacy students

USMLE, PLAB, FMGE, NEET PG preparation

Anyone looking for easy-to-understand pharmacology

📌 Part 2 will cover additional antihelminthic drugs and advanced clinical correlations.