The Wnt pathway in a normal and in a tumour cell
Автор: Onkoview
Загружено: 2010-02-22
Просмотров: 113345
Описание: In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein -catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of -catenin in the cytosol and also in the nucleus is increased. Nuclear -catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of -catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis.
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