Mink Mania, Positive Press Releases for Vaccines, and other news

Описание: This week we will be looking at some of the latest COVID news, and some of the latest scientific papers on SARS-CoV-2 that have caught our eye.

0:00 Theme
0:04 Introduction
1:07 Quick Summary of what we'll be covering
1:44 Mink Mania
13:14 BioNTech / Pfizer Vaccine News
25:15 Sputnik V & Moderna Press Releases
32:43 The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
35:53 Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic
37:59 Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19
42:05 Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum
43:05 Case Study: Prolonged infectious SARS-CoV-2 shedding from an asymptomatic immunocompromised cancer patient.
44:51 Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host
46:06 Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment
48:11 Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibility
51:14 De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2
53:35 Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
56:29 SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
57:42 Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain
1:00:21 We gotta choose something new
1:03:24 Outro


Sources
Mink Mania

SARS-CoV-2 mink-associated variant strain – Denmark 6 November
https://www.who.int/csr/don/06-novemb...

Detection of new SARS-CoV-2 variants related to mink -12th november
https://www.ecdc.europa.eu/sites/defa...

SARS-CoV-2 mink-associated variant strain – Denmark
https://www.who.int/csr/don/06-novemb...

SARS-CoV-2 spike mutations arising in Danish mink and their spread to 4 humans
https://files.ssi.dk/Mink-cluster-5-s...

Pfizer Vaccine News
Clinical Trial
https://clinicaltrials.gov/ct2/show/N...

Press Release
https://investors.pfizer.com/investor...

Other Vaccine News

Sputnik V Vaccine Press release
https://sputnikvaccine.com/newsroom/p...

Moderna Press release
https://investors.modernatx.com/news-...

Potential Papers

Evolution
The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
https://doi.org/10.1101/2020.11.04.35...

Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic
https://doi.org/10.7554/eLife.59633


Patient Studies
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19
https://doi.org/10.1126/scitranslmed....

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum
https://doi.org/10.1038/s41590-020-00...

Case Study: Prolonged infectious SARS-CoV-2 shedding from an asymptomatic immunocompromised cancer patient.
https://doi.org/10.1016/j.cell.2020.1...

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host
https://doi.org/ 10.1056/NEJMc2031364

Treatments

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment
https://doi.org/10.1101/2020.08.15.25...

Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibility
https://doi.org/10.1038/s41434-020-00...

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2
https://doi.org/10.1126/science.abe0075

Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
https://doi.org/10.1038/s41594-020-00...

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19
https://doi.org/10.1056/NEJMoa2029849

Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain
https://doi.org/10.1128/mBio.01935-20


If you have any papers you would like us to look into, message
@ID_Eater or @Defectivebrayne using #microtwjc

Check out our Zotero Library for other papers we may look at in future: https://www.zotero.org/groups/2491503...