Determination of pA2 value of Antagonists - Part1

Описание: |pA2| Antagonist| potency| pharmacology| CRC| Acetylcholine| Frog| isolatedtissue| GPAT| Experiment| Practical| Screening| Rat| Mice| Rabbit| Guineapig| pA2 is calculated to compute the potency of antagonist acting on same receptor. The pA2 value is defined as the negative logarithm of the molar concentration of the antagonist required to reduce the effect of multiple doses of the agonist to that of a single dose in the absence of the antagonist. The difference between pA2 and pA10 have wider applications. If the difference between the two values is found to be near 0.95 then the antagonism is likely to be competitive type. An antagonist acting on the same receptor will have same pA2 value in all the tissue or organ preparations. This video explains in a simple manner the concept and determination of pA2 value with suitable examples.
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Myself Dr. B. PREMKUMAR M.Pharm Ph.D working as the Professor and HOD in a reputed institution. I completed my graduation from JKK Muniraja college of Pharmacy and Post-graduation in Pharmacology from the Most prestigious Madras Medical College. I have Done My Doctorate in the most esteemed Jawaharlal Nehru Technological University Hyderabad (JNTUH). I am a CPCSEA nominee for Preclinical animal experimental pharmacological research. I have published my research work in reputed journals of national importance. I am also a reviewer in renowned journals.
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