MET｜Popular Gene Target of Lung Cancer Research

Описание: The MET gene encodes a prototypical receptor tyrosine kinase, which is involved in the tyrosine kinase signaling pathway that regulates cell motility, survival, proliferation, invasion, and metastasis in many cancers. In this article, we review the hottest oncogene MET, hoping to give you insights on its role in cancer development as a therapeutic target in lung cancer research.
Non-small cell lung cancer is the leading cause of cancer-related death worldwide with a poor prognosis. Although Non-small cell lung cancer research progress has been striking in terms of detection and treatment of the abnormal MET pathway type, there are few drugs targeting c-MET that are available. While the MET gene mutation not only leads to primary lung cancer, it is also a major cause of anti-lung cancer drug resistance, making it a driver gene in lung cancer.

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