Alpha Blockers Pharmacology: Phenoxybenzamine and Phentolamine Explained

Описание: In this video I talk about Alpha blockers, I start with a definition to alpha blockers then I Explain the mechaism of action of these drugs; after that I explain phenoxybenzamine and phentolamine mechanism of action and therapeutic uses...

Alpha blockers are drugs that competitively or irreversibly block the alpha receptors, alpha receptors are of two types 1 and 2; alpha 1 receptors are found in the vessels walls, iris dilator muscle, prostate, urethral sphincter, pylorus, and anal sphincter and their activation lead to contraction of smooth muscles; alpha 2 receptors are found in the sympathetic post ganglionic pre synaptic nerve terminals and their activation inhibit the release of norepinephrine...

Selective alpha blockers:    • Alpha Blockers Pharmacology: Prazosin, Dox...  

** Picture used in the thumbnail is licensed under creative commons licensing, credit: MorgueFile : see [1], CC BY-SA 3.0 https://creativecommons.org/licenses/..., via Wikimedia Commons

Video Timestamps
Intro: (0:00)
Definition: (1:01)
Mechanism of action: (5:39)
Phenoxybenzamine: (7:52)
Phentolamine: (14:43)