Stereochemistry of E2 reaction
Автор: ChemWis
Загружено: 2020-12-21
Просмотров: 15948
Описание: In an E2 reaction, a substrate, with a leaving group X and at least one beta hydrogen undergoes proton abstraction and removal of leaving group in the a single step to produce alkene. For the elimination to occur H and X should be anti-periplanar. If there are two beta-hydrogens trans-product is formed as major and cis-product as minor. In E2 reaction, stereospecificity can be observed if both the alpha and beta carbons are chiral. In such circumstances there is only one proton at beta carbon that can take part in elimination. In this case there is only one possible anti-periplanar transition state. So, whether the product is cis or trans will only depend on which diastereomer of the starting material is used.
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