2022 EASD: Novo Nordisk Foundation Diabetes Prize for Excellence, Professor Anette-Gabriele Ziegler

Описание: Diabetes was first described more than three millennia ago on Egyptian papyrus scrolls, so it has probably always plagued humanity. However, Anette-Gabriele Ziegler, one of the world’s leading clinical researchers on type 1 diabetes, thinks that this could soon end. Her development of innovative screening programmes has created pioneering new knowledge about the cause and can now pave the way for better prevention, earlier diagnosis and therapy aiming for a future world without type 1 diabetes. Anette-Gabriele Ziegler is receiving the EASD–Novo Nordisk Foundation Diabetes Prize for Excellence 2022 for her efforts to understand, prevent and combat type 1 diabetes.

0:00 Intro
0:07 The clock to type 1 diabetes starts
0:13 Development of type 1 diabetes and point of no return
0:25 Type 1 diabetes throughout history
0:31 Professor Anette Ziegler's recognition and contributions
0:39 Pioneering new knowledge about type 1 diabetes
0:55 Contributions to personalized prevention in children
1:11 Personal motivation and early experiences with type 1 diabetes
1:47 Education and early research career
1:56 Work at Joslin Diabetes Center with George Eisenbach
2:10 Inspiration to understand type 1 diabetes development
2:33 The Baby Diab Study and its significance
2:52 Understanding susceptibility to type 1 diabetes
3:19 The role of insulin antibodies in early diabetes
3:24 Early period as crucial for autoimmunity development
4:08 Long-term follow-up studies and landmark paper
4:43 Personal reflection and metaphor of the clock
5:15 Detection of multiple antibodies as a critical point
5:36 The immune system as the aggressor in type 1 diabetes
5:47 Efforts to re-educate the immune system
6:02 Various routes of insulin application
6:26 Promising success in delaying disease progression
6:40 Consolidation of 25 years of research
7:04 Development of genetic risk score for population screening
7:20 Establishing international research infrastructure
7:32 The FRIDA study in Bavaria, Germany
7:56 Preparing families for life with type 1 diabetes
8:24 Importance of early diagnosis and prevention of complications
8:49 Future goals for expanding screening and prevention
9:05 Steps ahead in diabetes research and prevention
9:17 Conclusion and hope for a world without type 1 diabetes