The Gut's Secret Language
Автор: AI News Network
Загружено: 2026-02-03
Просмотров: 57
Описание: These sources examine the *bacterial type III secretion system (T3SS)**, a complex nanomachine used by both **pathogens and gut commensals* to inject proteins into host cells. Researchers have developed *innovative assays**, such as those using **NanoLuc luciferase**, to monitor protein translocation kinetics and perform high-throughput screening for inhibitors. While traditionally viewed as a **virulence factor* in diseases like cholera or gastroenteritis, new evidence suggests the T3SS also facilitates *symbiotic relationships* by modulating human immune signaling. Structural studies utilize *cryo-electron microscopy* and *optogenetics* to understand how these "syringes" recognize host contact and select specific cargo. Furthermore, scientists are exploring how to *reengineer these systems* for targeted delivery in medical applications like *gene and cancer therapy**. This body of work highlights the T3SS's dual role in **maintaining health and driving infection* within the human microbiome.
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