Ionization, Solubility & Log P in relation to Biological Activity | Med Chem-I | B.Pharm Semester IV

Описание: In this detailed lecture, we cover one of the most important and high-scoring topics of Medicinal Chemistry-I:
Complete Notes -https://shorturl.at/KdcI6

🔬 Ionization (pKa)
💧 Solubility
🧪 Partition Coefficient (Log P)

These physicochemical properties directly determine:

✔ Drug absorption
✔ Membrane permeability
✔ Bioavailability
✔ Distribution
✔ CNS penetration
✔ Biological activity

Remember:
👉 Before a drug acts, it must reach the receptor.

In this lecture, you will clearly understand:

📌 Why only unionized drugs cross membranes
📌 Weak acids and weak bases concept
📌 How pKa determines site of absorption
📌 “No Dissolution = No Absorption” concept
📌 Hydrophilic vs Lipophilic balance
📌 What is log P and why it is important
📌 Lipophilicity and membrane penetration
📌 CNS drugs and partition coefficient
📌 Examples: Aspirin, Morphine, Thiopental, Phenobarbital

This lecture is specially designed for:

🎓 B.Pharm Semester IV
🎓 D.Pharm Students
🎓 GPAT Aspirants
🎓 NIPER Preparation
🎓 University Exams

This topic is frequently asked in:

✔ Long answer questions
✔ Short notes
✔ MCQs
✔ Viva
✔ Competitive exams

🔔 Stay Connected

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Let’s make Medicinal Chemistry simple together ❤️


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