Why T3/T4 Labs Don’t Match Symptoms

Описание: Today’s pearl: Serum thyroid hormones don’t always reflect intracellular action, especially with inflammation.

During illness/inflammation, local deiodinases shift inside tissues: in acute skeletal muscle, D2 (“gas”) rises and D3 (“brake”) falls (↑ intracellular T3), while liver/adipose can show the opposite.

During chronic states, patterns vary by tissue.

Translation: tissue thyroid action ≠ serum T3/T4/rT3, so labs may not match symptoms.

Clinical use: When labs and symptoms disagree, screen for inflammation/illness, avoid knee-jerk T3/T4 tweaks, and treat the underlying cause. We teach the full workflow in our Advanced Mentorship → metabolicfitnesspro.com

#Thyroid #T3 #T4 #ReverseT3 #Deiodinase #Inflammation #ClinicalPearls #FunctionalMedicine #EvidenceBased