Menopause and ADHD

Описание: Main Chapters:
00:00 Intro - Menopause and ADHD
00:20 Take home message
01:48 What is Menopause?
07:37 Potential Effects of Menopause on Brain Functions
09:53 Studies on Menopause and ADHD-Like Symptoms
20:26 Conclusion

As of the end of 2024 there are no studies examining women with ADHD before, during, and after their perimenopausal years. This reflects how medicine in general has relatively ignored women, ignored the importance of menopause, and not recognized the importance of ADHD in women.

Nevertheless, research indicates that many women experience concentration, attention, memory and mood regulation issues during perimenopause (when estrogen and progesterone doses are fluctuating) and in menopause (where levels of these two hormones are minimal). Robust concentrations of estrogen receptors in the prefrontal cortex, involved in executive functions, are thought to be how menopause may impact brain function. The impairment of many women during perimenopause appears to be as severe as those who have full blown ADHD.

Preliminary evidence suggests that diminished estrogen levels result in less dopamine and more glutamate in the prefrontal cortex, and that treatments including hormonal replacement therapy, atomoxetine, and lisdexamfetamine can help reduce ADHD symptoms.

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Free link to my Medium article on Menopause and ADHD:
https://medium.com/wise-well/the-brai...

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References:
Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women (2011)
https://pmc.ncbi.nlm.nih.gov/articles...

New onset executive function difficulties at menopause: a possible role for lisdexamfetamine (2015)
https://link.springer.com/article/10....

Cognitive Problems in Perimenopause: A Review of Recent Evidence (2023)
https://link.springer.com/article/10....

Full Chapter list:
00:00 Intro - Menopause and ADHD
00:20 Take home message
01:48 What is Menopause?
02:28 Symptoms in Perimenopause and Post-Menopause
04:29 Potential Medical Interventions for Menopausal Symptoms
06:21 Difficulties in Researching the Effects of Menopause
07:37 Potential Effects of Menopause on Brain Functions
08:46 Impact of Hormones on the Brain
09:53 Studies on Menopause and ADHD-Like Symptoms
10:53 Evaluating ADHD Symptoms with the BADDS Scale
12:22 Study on Atomoxetine and Menopause
14:45 Study on Vyvanse and Menopause
18:02 Study on Vyvanse and Menopause Using Brain Imaging
19:54 Study on Hormone Replacement Therapy and Menopause
20:26 Conclusion
22:41 Outro

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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions.
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