BREEZULA Update: When Can You Use It For Hair Growth?

Описание: The Truth About Hair Loss -    • Hair Loss Industry Exposed! - How I regrew...  

It’s been over 20 years since the FDA last approved a drug for baldness. That drug was finasteride. And today, we're looking at Breezula.

But that could very soon be changing. There’s a new drug in middle to late stages of clinical development. It’s called clascoterone, and it promises to do something very similar to finasteride, but in a topical solution.

And if believe the manufacturer, there will be hardly any side effects. Could this be the beginning of the end for minoxidil? You’ll find out in today’s video.


 Timestamps:
📌0:00 - Intro
📌1:08 - What is clascoterone? How does it work?
📌3:17 - The research to date
📌7:18 - The side effects
📌7:50 - When can we expect breezul to hit the market?

Transcription:

So the company behind this drug are called Cassiopea

They’re a small Italian pharmaceutical, publicly traded in the Swiss stock exchange.

The company’s main focus is dermatological.

They develop treatments for acne, genital warts and baldness.

Currently there are three products in their R&D pipeline.

But the big one is clascoterone.

Cassiopea own the rights to this drug at least till 2028, with the option to extend beyond that.

And they are currently trying to get it FDA-approved both as a liquid solution for hair loss, as well as a cream for acne.

The proposed brand names of clascoterone are Winlevi for the acne cream, and Breezula for hair loss.

What is clascoterone, and how does it work?

Clascoterone combats hair loss by blocking the androgen receptor.

The androgen receptor is the target destination of the male hormone family, the so-called androgens.

Including the most potent androgen of all, dihydrotestosterone (DHT).

DHT has been known for decades to be the molecule directly implicated in androgenetic alopecia.

The DHT in the scalp binds to the androgen receptors inside the hair follicles and activates them.

Once activated, the androgen receptors set in motion a cascade of biochemical reactions inside follicle cells, like regulating various genes’ expression.

Which of these biochemical reactions is responsible for causing baldness is not yet clear.

But we know for a fact that stopping DHT from activating the androgen receptor arrests the progression of baldness, at least for a majority of men.

So when applied on the scalp, clascoterone interacts with the androgen receptors inside the hair follicles and surrounding sebaceous glass.

Clascoterone is a) similar enough to an androgen to bind to the androgen receptor, and b) different enough to not activate it.

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Reference Links:
https://www.cassiopea.com/
https://europepmc.org/article/med/312...
https://www.cassiopea.com/2017/12/11/...
https://www.cassiopea.com/2019/04/16/...
https://www.cassiopea.com/wp-content/...

Disclaimer
This video is for educational purposes only and is not intended to treat, diagnose or cure any disease.