Negishi cross-coupling reaction
Автор: Chem Help ASAP
Загружено: 2020-02-13
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The Negishi cross coupling reaction involves the reaction of an aryl halide (R-X) with an organozinc reagent (R'-ZnBr) in the presence of a palladium catalyst to form a biaryl (R-R'). The organozinc can be formed from a halide (R'-X). The halide is treated with either magnesium or lithium to make a Grignard or organolithium, which in turn is treated with ZnBr2 to make the organozinc. Because the organozinc is not highly nucleophilic, the Negishi coupling can tolerate many different functional groups on the biaryl product, especially on the halide coupling partner.
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