Convergent Pathology: How Autism and Alzheimer's Meet at the mTOR Pathway
Автор: AI News Network
Загружено: 2026-03-04
Просмотров: 45
Описание: Scientific research indicates a significant molecular link between *Autism Spectrum Disorder (ASD)* and *Alzheimer’s disease (AD)**, specifically through the **mTOR signaling pathway**. Studies using mouse models, such as those with **Shank3* and *Cntnap2* mutations, reveal that *hyperactive Akt-mTOR signaling* contributes to core deficits like impaired social interaction. By employing *SNOTRAP-based mass spectrometry**, researchers identified that **S-nitrosylation**, a protein modification driven by nitric oxide, targets key proteins shared by both conditions. Experimental evidence shows that pharmacological inhibitors like **rapamycin* can reversibly restore social behaviors in these models, though they may not affect hyperactivity or repetitive interests. Ultimately, these findings suggest that targeting the *mTOR pathway* offers a promising therapeutic strategy for treating diverse neurodevelopmental and neurodegenerative pathologies.
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