Total Synthesis of (−)-Peyssonnoside A

Описание: An organic chemistry minilecture on the 13-Step Total Synthesis of (−)-Peyssonnoside A by Bo Xu, Chang Liu, and Mingji Dai* It features some excellent metal catalysed C-C bond forming chemistry, including a Cu-catalysed asymmetric conjugate addition, a Pd- catalysed dearomative cyclization and Wittig reaction with the Lebel modification.



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References:
J. Am. Chem. Soc. 2022, 144, 19700−19703 (This work)
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Eur J Org Chem, 2012, 27, 5301–5306 (Cu-NHC catalyzed Michael addition)
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hydration)
J. Am. Chem. Soc. 2021, 143, 14083−14088 (Endgame)