Autophagy: Mechanism, Regulation and Importance of Autophagy in Clinical Medicine

Описание: This video explains about Autophagy: Mechanism of Autophagy, Regulation of Autophagy and the Importance of Autophagy in Clinical Medicine.

Autophagy is derived from the Greek word, Auto meaning “Self” and phagein meaning “to eat”.

Autophagy is a highly conserved pathway that degrades cellular components, such as defective organelles and aggregates of misfolded protein, through lysosomes. 

Autophagic process is meant for regulating diverse cellular functions including:

1. Growth,
2. Differentiation,
3. Response to nutrient deficit and oxidative stress,
4. Cell death, and
5. Macromolecule and organelle turnover.

Types of Autophagy:
1. Macroautophagy
2. Microautophagy
3. Charperon Mediated Autophagy

Discussion about Autophagy Inducers and Inhibitors and Autophagy as a Double Edged Sword.

Reference Articles:
Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
Valdenizia R. Silva, Sara P. Neves, Luciano de S. Santos, Rosane B. Dias and Daniel P. Bezerra

An Overview of Autophagy: Morphology, Mechanism, and Regulation
Katherine R. Parzych and Daniel J. Klionsky

An overview of autophagy: Mechanism, regulation and research progress
Weiya Cao, Jinhong Li, Kepeng Yang, Dongli Cao

AutophagyMechanism, Regulation, Functions, and Disorders
Mallikarjun Badadani

Clinical Applications of Autophagy Feature

Autophagy as a double-edged sword
https://www.med.uio.no/cancell/englis...

Research Papers: Yoshinori Ohsumi
Autophagy in Yeast Demonstrated with Proteinase-deficient
Mutants and Conditions for its Induction
Kazuhiko Takeshige, Misuzu Baba, Shigeru Tsuboi, Takeshi Noda, and Yoshinori Ohsumi

Isofation and charact~~zation of autophagy-defective mutants of Saccharomyces cerevisiae
Miki Tsukada, Yoshinori Ohsumi

A protein conjugation system essential for autophagy
Noboru Mizushima, Takeshi Noda, Tamotsu Yoshimori,
Yae Tanaka, Tomoko Ishii†, Michael D. George,
Daniel J. Klionsky, Mariko Ohsumi† & Yoshinori Ohsumi

A ubiquitin-like system mediates protein lipidation
Yoshinobu Ichimura, Takayoshi Kirisako*²³, Toshifumi Takao§,
Yoshinori Satomi§, Yasutsugu Shimonishi§, Naotada Ishihara,
Noboru Mizushima k, Isei Tanida, Eiki Kominami¶, Mariko Ohsumi#,
Takeshi Noda*² & Yoshinori Ohsumi

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