Life Purpose & Research Design In Integrative Medicine With Dr. Heather Zwickey, PhD (Zwickey, 2024)

Описание: Join Dr. Heather Zwickey (phD) for an in-depth exploration of research design in the context of integrative medicine and health. This session breaks down the critical steps of navigating the research landscape, from reading scientific literature to understanding the biological impact of life purpose on the immune system.

Dr. Zwickey explains complex methodologies including the PICO framework, randomized controlled trials, and observational studies. She also dives into the science of happiness, comparing eudaimonic and hedonic well-being, and discusses the future of healthcare models that incentivize wellness rather than disease.

I. Navigating The Research Landscape
Start research by learning the current state of the science.
Read 20 to 30 papers to build a foundation and find gaps.
Read review articles first and basic science papers last.
Use a reference manager like Zotero to track your reading.
Use the PICO format to summarize or design clinical studies.
PICO stands for Participants, Intervention, Comparison, and Outcome.
Check author affiliations to see where research is happening.
Use NIH Reporter to see what grants are currently funded.

II. Types Of Study Designs
Experimental studies involve doing something to a participant.
Observational studies observe choices without intervening.
Cohort studies look forward in time at exposed groups.
Case control studies look backward to identify exposures.
Cross-sectional studies look at data at a single point in time.
Secondary data analysis uses existing data for new questions.
Case studies document interesting cases and track outcomes.
Randomized controlled trials are the gold standard for causality.
Quasi-experimental studies often use pre-post analysis.
Pragmatic trials test if a treatment works in the real world.
Whole systems research allows clinicians to treat holistically.
Qualitative data is gathered through focus groups and interviews.

III. Life Purpose And Health Outcomes
Happiness is often viewed as intrinsic and based on perception.
Eudaimonic happiness comes from meaning and self-actualization.
Hedonic happiness focuses on fleeting pleasure and enjoyment.
Hedonic happiness is linked to higher inflammation and stress.
Eudaimonic well-being correlates with better immune function.
Ikigai is the intersection of passion, mission, vocation, and job.
Lack of life purpose is linked to substance use and suicidality.
Physiological response is linked to psychological response.

IV. The Future Of Health Research
The current medical model profits when patients remain sick.
Future systems should incentivize health rather than disease.
Postbiotics and the microbiome are key areas for new therapies.
Microbes in the gut produce essential neurotransmitters.
Case reports are vital for funding and understanding individuals.
Transforming healthcare requires a focus on the whole person.

V. Source
NourishED Research Foundation. (n.d.). Navigating Research with Dr. Heather Zwickey | Intro to Naturopathic & Biomedical Research [Video]. YouTube.

VI. Additional Resources
For additional resources, please check out our NotebookLM Resource Support Page: https://notebooklm.google.com/noteboo...

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