2-Minute Neuroscience: Brown-Séquard Syndrome

Описание: Brown-Séquard syndrome is a rare neurological condition caused by damage to one side of the spinal cord, a situation referred to as hemisection of the spinal cord. This type of damage results in a distinct pattern of deficits due to the way different nerve tracts travel through the spinal cord. In this video, I describe the neurological deficits in Brown-Séquard syndrome and the reasons behind their characteristic pattern.

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TRANSCRIPT
Brown-Sequard syndrome is a rare neurological condition caused by damage to one side of the spinal cord, a situation referred to as hemisection of the spinal cord. This type of damage results in a distinct pattern of deficits due to the way different nerve tracts travel through the spinal cord.

Brown-Sequard syndrome involves weakness or paralysis below the hemisection on the same side of the body as the damage, because the spinal cord damage affects the corticospinal tract. The corticospinal tract carries movement signals from the brain, and it decussates–or crosses over–in the brainstem before continuing down into the spinal cord. The corticospinal tract on one side of the spinal cord is thus carrying movement signals intended for the same side of the body, so when it is damaged those signals can’t reach that side of the body below the injury, leading to weakness or paralysis on that side.

Damage to one side of the spinal cord would also result in deficits in touch, proprioception, and vibration sense below the hemisection on the same side of the body as the damage. These deficits are caused by damage to the dorsal column, which carries these types of sensations up the spinal cord from the same side of the body. Although the pathway does cross over, this doesn’t occur until it reaches the brainstem, so spinal cord damage to the pathway causes deficits on the same side as the damage.

Brown-sequard syndrome also causes deficits in pain and temperature sensation due to damage to the spinothalamic tract. The spinothalamic tract fibers cross over soon after entering the spinal cord. Thus, the right side of the spinal cord is carrying pain and temperature sensations from the opposite side of the body. Therefore, pain and temperature deficits in Brown-sequard syndrome are experienced on the opposite side of the body below the hemisection.


REFERENCES
Haines DE. Fundamental Neuroscience for Basic and Clinical Applications. 4th ed. Philadelphia, PA: Elsevier; 2013.

Shams S, Davidson CL, Arain A. Brown-Séquard Syndrome. 2024 Feb 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 30844162.

Vanderah TW, Gould DJ. Nolte's The Human Brain. 8th ed. Philadelphia, PA: Elsevier; 2021.


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