Mannich Reaction || Organic Name Reactions
Автор: PaathShaaala
Загружено: 2021-08-12
Просмотров: 573
Описание:
The Mannich reaction is an organic reaction that consists of an amino alkylation of an acidic proton placed next to a carbonyl functional group by formaldehyde and a primary or secondary amine or ammonia. The final product is a β-amino-carbonyl compound also known as a Mannich base.
Reactions between aldimines and α-methylene carbonyls are also considered Mannich reactions because these imines form between amines and aldehydes. The reaction is named after chemist Carl Mannich.
The Mannich reaction is an example of nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Schiff base.
The Schiff base is an electrophile that reacts in the second step in an electrophilic addition with a compound containing an acidic proton (or had become an enol). The Mannich reaction is also considered a condensation reaction.
#Mannich
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