Protein Sequence Alignment in Theory and Practice
Автор: Gabriel Axel
Загружено: 2023-05-23
Просмотров: 1469
Описание:
00:37 Sequence identity and similarity
01:39 BLOSUM62 substitution matrix
04:27 Gaps
04:49 Effects of mutations
06:35 Multiple sequence alignment
07:50 Conserved positions
08:32 ClustalOmega and WebLogo demo
10:10 Secondary structure prediction
10:51 Quick2D demo
11:46 Co-evolution and contacts
12:42 Structure prediction process
We start with a non-technical introduction to the concepts of sequence identity and sequence similarity, what makes amino acids similar, and how sequence similarity relates to evolution. We continue to explaining how multiple sequence alignment can be used to understand and predict protein structure and function. The explanations are accompanied by demonstrations of sequence alignment and structure prediction using freely accessible programs on the internet.
BLOSUM interactive graph: http://ahmetrasit.com/blosum/
MPI Bioinformatics Toolkit: https://toolkit.tuebingen.mpg.de/
WebLogo 3 - MSA Logo creation: https://weblogo.berkeley.edu/logo.cgi
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