BMAC vs PRP for Knee Osteoarthritis | Systematic Review & Meta-Analysis, Indian Journal of Pain 2025

Описание: In this Journal Club session, we present and discuss a systematic review and meta-analysis comparing Bone Marrow Aspirate Concentrate (BMAC) versus Platelet-Rich Plasma (PRP) for knee osteoarthritis. The paper was published in the Indian Journal of Pain (Volume 39) on 9 December 2025 and followed PRISMA 2020 methodology with PROSPERO registration.

What you will learn in this session:
Why orthobiologics are increasingly used in knee OA
Key biological mechanisms: PRP growth factors vs BMAC cellular + cytokine effects
Study selection (PRISMA flow), included studies, outcomes and follow-up points
Primary outcome: Pain reduction (VAS/KOOS pain components)
Secondary outcomes: Function improvement (WOMAC, IKDC)
Risk of bias assessment (RoB2, Newcastle–Ottawa Scale)
Clinical implications: when PRP is enough vs when BMAC may be preferred

Key takeaways from the meta-analysis discussion
Pain relief: BMAC and PRP showed comparable pain reduction at 1, 3, 6, 9, and 12 months.
Function: BMAC showed modest superiority in IKDC at several time points (notably 3, 6, and 12 months).
Safety: Both therapies demonstrated excellent safety profiles, mostly minor transient discomfort/swelling.
Heterogeneity: Significant variability existed across studies; sensitivity analysis clarified some functional advantages of BMAC.
Additional clinical discussion points covered
Why some patients respond poorly to PRP (inflammatory arthropathy overlap, nociplastic pain, selection factors)
Role of ultrasound guidance and injection plane considerations
PRP with high molecular weight hyaluronic acid: practical insights
Managing OA with effusion, NSAID timing, rehab and “prehabilitation” principles
Practical questions from participants (meniscal PRP, subchondral approaches, DMARDs, antiplatelets, etc.)

Citation / Source
Indian Journal of Pain | Published: 9 Dec 2025
Topic: Efficacy of BMAC vs PRP in Knee Osteoarthritis (Systematic Review & Meta-Analysis)

For clinicians and trainees
This video is intended for educational purposes and reflects journal club discussion and clinical perspectives. Treatment decisions must be individualized.

Hosted/Moderated by: Dr. Gautam Das
Presented by: Fellowship team (Journal Club)

#PRP #BMAC #Orthobiologics #DARADIAfellows #RegenerativeMedicine

This youtube channel is the official youtube channel of Daradia: The Pain Clinic which is a pain relief clinic with an official website https://daradia.com.
You can also reach us by telephone or WhatsApp +919339657857
Daradia is regularly publishing scientific information to guide common people so that they remain updated with the most modern development in the field of pain management which is authentic and based on published literature. Daradia condemns unscientific information and promotional videos based on wrong information. Daradia is working on pain awareness of different issues related to pain management that are commonly searched on youtube and googles like: "pain management clinic", "lancinating pain", "knee pain while bending", "diabetic leg pain", "burning sensation in knee", "nerve pain in knee", "pain in extremities", "pinched nerve healing signs", "knee specialist", "shoulder injury recovery", "frozen shoulder pain relief at night", "pain management clinic what to expect", "pain relief clinic kolkata", "pain specialist doctor", "knee pain old age", "pain management doctors", "relief clinic", "pain clinic Kolkata", "middle back pain relief", "leg pain due to diabetes", "locked knee treatment", "shoulder sprain treatment", "pain clinic procedures", "pain clinic video", "neuro pain clinic", "pain clinic management" etc.