Identifying the root-cause of polysorbate degradation
Автор: Alphalyse A/S
Загружено: 2024-04-09
Просмотров: 3315
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Do you experience polysorbate degradation – but don’t know the cause?
One of our mAb clients struggled with polysorbate degradation, affecting the efficacy and safety of their drug product.
The client suspected the problem was a host cell protein – a lipase – which co-purified with the mAb through Protein A purification.
But without knowing the identity or characteristics of the culprit, they were unable to remove it from the final drug product.
Watch this video to learn how we identified the lipase (lipoprotein - LPL) responsible for polysorbate degradation and enabled the client to control it.
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