Ozempic Prevents Multiple Sclerosis?

Описание: A study done on the US Food and Drug Administration Adverse Event Reporting System (FAERS) surprisingly showed that people taking certain weight loss drugs appear to have a dramatically lower risk of multiple sclerosis. Is this real? I review the study and show some of the problems with the methodology and the theory behind a possible association of MS with obesity.

The article I am discussing: https://pubmed.ncbi.nlm.nih.gov/38566...

Selected Sources:

Association of obesity with disease outcome in multiple sclerosis: https://pubmed.ncbi.nlm.nih.gov/36319...
Association of Obesity With Multiple Sclerosis Risk and Response to First-line Disease Modifying Drugs in Children: https://pubmed.ncbi.nlm.nih.gov/31305...
Dulaglutide Modulates the Development of Tissue-Infiltrating Th1/Th17 Cells and the Pathogenicity of Encephalitogenic Th1 Cells in the Central Nervous System: https://www.ncbi.nlm.nih.gov/pmc/arti...
Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome: https://pubmed.ncbi.nlm.nih.gov/35364...
GLP-1 Analogs: https://tmedweb.tulane.edu/pharmwiki/...
Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome: https://www.neurology.org/doi/10.1212...
Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection: https://www.mdpi.com/1422-0067/21/21/...
Metformin as a Potential Agent in the Treatment of Multiple Sclerosis: https://www.ncbi.nlm.nih.gov/pmc/arti...


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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.