Why Do People Keep Falling For Things That Don't Work? The Mechanistic Bias

Описание: There’s one particular mental trap that seems to fool everyone, especially those WITH medical knowledge.

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My video on vaccines and people’s reactions:    • What Is The Future For Vaccines (and Trust)?  
My video on bias, which mentions other failed therapies (two parter):    • How Medical Research Gets It Wrong (Medica...  

Kevin Klatt’s post   / cb72yxvlcf3  
Andrew Steele’s dissection of ‘Blueprint’ longevity plan    • Can ‘Blueprint’ make you biologically youn...  

Writing: Rohin Francis
Editing: Tanmay Nandanikar and Rohin Francis
Thumbnail design: Simon Buckmaster

0:00 Intro
3:41 The demarcation problem
6:44 Pseudoscience
9:06 Homeopathy and chiropractic
11:20 It's nice to feel nice
13:37 Bioplausibility
16:39 The mechanistic bias
17:06 Hard vs soft; clean vs messy science
20:25 Mechanistic examples: COVID Rx and masks
24:40 Diets
28:12 Vitamin D supplements
36:36 The Big Pharma graveyard
45:33 Most therapies don't work
47:07 Influencers' love of sexy mechanisms
50:25 Closing summary


References:

Convalescent plasma doesn’t work https://www.thelancet.com/journals/la...
Meta-research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals https://elifesciences.org/articles/45183
Most healthcare interventions don’t work https://www.jclinepi.com/article/S089...
COVID experts give Thanksgiving tips https://www.statnews.com/2022/11/21/h...
VITAL study (vitamin D) https://www.nejm.org/doi/full/10.1056... https://www.nejm.org/doi/full/10.1056...
VITAL website https://www.vitalstudy.org/index.html
Vitamin D in kids https://jamanetwork.com/journals/jama...
MAST pants don’t work https://pubmed.ncbi.nlm.nih.gov/10796...
Nesiritide https://www.ahajournals.org/doi/10.11...
REDOX https://www.nejm.org/doi/10.1056/NEJM...
PANTHER IPF https://www.nejm.org/doi/10.1056/NEJM...
OSCILLATE https://www.nejm.org/doi/10.1056/NEJM...

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