Serotonin, Autism and the Immune System - Randy Blakely PhD, BRAIN Foundation Synchrony 2023

Описание: Serotonin is a powerful neuromodulator in the brain that’s involved in regulation of mood, habit, reward, anxiety, and social behavior. The targets of serotonin also include major peripheral processes that range from vasoconstriction and blood clotting to intestinal and placenta function. Dr Blakeley’s lab first identified the gene encoding the antidepressant-sensitive serotonin transporter (SERT, 5-HTT, SLC6A4), and over the past three decades they have elucidated mechanisms that regulate the activity of SERT protein, as well as factors that perturb these processes.

They have found the inflammatory cytokine IL-1B to be one of the major factors that regulates SERT and observed how mutation SERT mutation in mice drives reversible changes in central nervous system physiology, behavior and gut function. In this Synchrony 2023 talk Dr Blakeley discusses recent findings that IL-1b modulates serotonin signaling through somatic and axonal IL-1 receptors mediated by p38a MAPK signaling, with consequent changes in a distributed pattern of forebrain circuit activity that can be normalized using genetic and pharmacological approaches.

🎥 This talk was part of Synchrony 2023 Online Symposium - 'From Bench to Biopharma', organised by the The BRAIN Foundation

🎥 Synchrony 2023 playlist:    • Synchrony Symposium 2023  

Synchrony https://brainfoundation.org/synchrony... is the first and only international symposium on translational research in #autism, that brings together academia, #biotech, #pharmaceuticalcompanies and venture partners from around the world with the mission to improve health and quality of life of people with #autismspectrumdisorder.


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The BRAIN Foundation https://brainfoundation.org/ is a 501c(3) non-profit. The founders of BRAIN envision a world where every child and adult on the autism spectrum is healthy, participates fully in education and employment, and has a better quality of life. It aims to catalyze research that results in evidence-based interventions for the disabilities associated with autism, and also results in better medical standard of care. To accomplish this, it funds impactful research through #philanthropy and our network of partners in the venture, corporate, and grassroots community.