Cancer: Emerging Hallmarks and Enabling Characteristics

Описание: The hallmarks of cancer – a phrase originally coined by Doug Hanahan and Bob Weinberg – comprise six biological capabilities acquired during cancer development: sustained proliferative signaling, the evasion of growth suppression, resistance to cell death, replicative immortality, angiogenesis, and invasion and metastasis. Over the past decade, two new hallmarks have emerged: reprograming of cellular energy metabolism and the evasion of immune destruction. These hallmarks are driven and sustained by genomic instability and inflammation. This session, encompassing seven talks, will address many of these hallmarks and enabling characteristics, a greater understanding of which is central to improved diagnostic, preventative and therapeutic approaches to cancer.

Co-Chairs: Niall Howlett (RI), Sherine Elsawa (NH). Mini Keynote: Mary Jo Turk (NH)

Introduction (0:00)
Co-Chair: Niall Howlett, PhD. PI MARC/U*STAR. University of Rhode Island, Professor, Cell and Molecular Biology.
Co-Chair: Sherine Elsawa, PhD, NH-COBRE Center for Integrated Biomedical & Bioengineering Research (CIBBR). University of New Hampshire, Associate Professor, Molecular, Cellular and Biomedical Sciences .

Resident memory T cell responses to cancer (2:34)
Speaker: Mary Jo Turk, PhD. The Geisel School of Medicine at Dartmouth, O. Ross McIntyre, M.D. Professor, Norris Cotton Cancer Center

Immunotherapy options for Pediatric Acute Myelogenous Leukemia: From target identification to clinical trial (26:37)
Speaker: Sonali Barwe, PhD. Alfred I. duPont Hospital for Children (DE), Senior Research Scientist, Cancer Modeling Laboratory

Molecular predictors of central nervous system recurrence in aggressive lymphomas (48:15)
Speaker: Adam J. Olszewski, MD. Lifespan Cancer Institute at Rhode Island Hospital. Alpert Medical School of Brown University Associate Professor of Medicine

Novel role for GLI2 in malignant B cells and the tumor microenvironment (1:10:50)
Speaker: Sherine Elsawa, PhD. NH-COBRE Center for Integrated Biomedical & Bioengineering Research (CIBBR). University of New Hampshire, Associate Professor Immunology, Molecular, Cellular and Biomedical Sciences

Development and implementation of a pediatric oncology genomics program: a focus on leukemias and the development of next generation sequencing techniques (1:27:40)
Speaker: Erin Crowgey, PhD. Director of Medical Bioinformatics, Nemours Children’s Hospital (DE) Alfred I. duPont Hospital for Children NEMOURS/DE-CTR ACCEL Research Scientist

Role of STAT3 in ovarian cancer (1:48:50)
Speaker: Sarah Walker, PhD. University of New Hampshire Assistant Professor, Molecular, Cellular and Biomedical Sciences

PIM1 kinase: A novel target in renal cell carcinoma (2:05:06)
Speaker: Sheldon Holder, MD, PhD, Brown University and Lifespan Cancer Institute (LCI), Assistant Professor of Pathology and Laboratory Medicine