Unconventional lipid-antigen recognition by group 1 CD1 restricted T cells

Описание: Unconventional lipid-antigen recognition by group 1 CD1-restricted T cells
Dr Adam Shahine, Monash University

This webinar explores emerging mechanisms of lipid antigen presentation and T-cell recognition mediated by group 1 CD1 molecules, with a particular focus on CD1c. Drawing on recent structural, biochemical, and lipidomic insights—including findings reported in Nature Communications—the talk examines how CD1-restricted T cells recognise complex lipid antigens beyond classical peptide–MHC paradigms.

Key themes include:
• Non-peptide antigen presentation through CD1 and MR1 systems
• Structural models of CD1–TCR interaction and docking mechanisms
• Novel insights into CD1c-mediated ganglioside presentation
• Integration of lipidomics, mass spectrometry, and cryo-EM in antigen discovery
• Implications for infection, autoimmunity, cancer, and tissue immunity

This webinar series is part of the Unravelling T Cell Recognition: Insights from Immunology and AI webinar series — an ImmunoIntelligence initiative dedicated to making rigorous immunology at the interface with data science, technology, and AI openly accessible to a global audience.

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Speaker: Dr Adam Shahine, Monash University
Host: Prof Hashem Koohy, University of Oxford
Series: Unravelling T Cell Recognition
Platform: ImmunoIntelligence
Support: ImmSilico


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