Cerebral Organoids to Model Seizures | Coffee Break Webinar ☕ | Dr. Robert Halliwell

Описание: Join Dr. Robert Halliwell from the University of the Pacific as he discusses how human cerebral organoids are being used to better understand epilepsy and accelerate the discovery of new anti-seizure medicines.

In this presentation, Dr. Halliwell explains how his lab combines human stem cell–derived brain organoids with Maestro multi-electrode array (MEA) technology to record neural activity, model epileptiform (seizure-like) patterns, and assess the effects of anti-seizure drugs.

🔍 In this 13-minute webinar, you’ll learn:
How human brain organoids replicate key features of neural networks
How epileptiform activity can be induced and recorded in vitro
The role of GABAergic and glutamatergic signaling in seizure modeling
How anti-seizure drugs such as diazepam, ethosuximide, and carbamazepine affect network activity
Why organoids provide a human-relevant, ethical alternative to animal models in neuroscience research

⌚ Timestamps:
00:00 Introduction
00:24 About Dr. Robert Halliwell
01:03 Why model epilepsy and seizures?
01:48 From animal models to human stem cells
03:18 What is epilepsy and why new treatments are needed
03:52 Creating cerebral organoids from human stem cells
04:46 Recording brain activity with MEA technology
07:36 Testing neural activity and drug responses
09:01 Inducing seizure-like activity in organoids
09:53 Anti-seizure drugs and results
10:53 Key findings and conclusions
12:12 Acknowledgments and closing

☕ About the Coffee Break Webinar Series
The Coffee Break Webinar Series by Axion BioSystems spotlights innovative applications of microelectrode array (MEA), impedance, and live cell imaging-based technologies across biological research.

Have questions or want to present your own research?
📧 [email protected]

#CerebralOrganoids #EpilepsyResearch #Neuroscience #AxionBio #StemCells #DrugDiscovery #Organoids #CoffeeBreakWebinar