Orthobiologics: Hype vs. Reality with Dr. Scott Rodeo

Описание: In this episode, Dr. Scott Rodeo, a leading orthopedic surgeon, explains the enormous potential of regenerative medicine in orthopedics. The episode explores how orthobiologics offer new hope for millions suffering from musculoskeletal diseases and pain, while also providing a clear-eyed view of the field’s challenges. Dr. Rodeo highlights innovative practices in orthopedic research, particularly focusing on stem cell therapy and its uses in osteoarthritis management. He discusses how these advancements could revolutionize treatments by targeting symptoms and examines whether they may be able to go further and modify cell structures in the future.

Note: This lecture was recorded in March 2023.

Learn more about Dr. Scott Rodeo’s work: https://www.hss.edu/physicians_rodeo-...

Learn more about Dr. David Dodick: https://www.atria.org/doctors/dr-davi...

Time stamps:
00:00:17: Intro
00:02:14: Dr. Scott Rodeo
00:03:05: The potential and limitations of regenerative medicine
00:06:08: Understanding stem cells
00:12:25: Mesenchymal STROMAL (MSC) cells and connective tissue progenitors
00:14:20: The availability and limitations of stem cells for clinical use
00:18:00: How might exogenous cells work?
00:20:24: Regulatory constraints on cell sorting and expansion
00:23:14: Why biologics can be symptom-modifying but are not likely to be structure-modifying
00:24:27: Biologic targets in treatment and tailoring therapy to the underlying pathology
00:26:55: The role of cell therapy in treating osteoarthritis
00:28:03: Inflammation in osteoarthritis and cell therapy
00:30:35: Role of cells in modifying local inflammatory environment
00:34:49: MSCs as a strategy to target macrophages in osteoarthritis
00:36:15: Research shows cells can have a positive effect on knee osteoarthritis
00:42:00: Are stem cells structure-modifying? Research shows significant potential
00:46:56: Studies show non-cultured cells show promise too
00:48:24: The potential and future approaches of cell therapy

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About:
Atria’s Vanguard Symposia is a lecture series where some of the world’s most compelling researchers translate leading-edge science into medicine. In each episode, top experts share breakthrough science about preventive health care, dive deep into headline-grabbing topics, and take you beyond the buzzwords to explain the latest in longevity science. Our show will arm you with practical information and the tools of discernment to cut through the hype and understand what matters most.

Atria Health and Research Institute aims to accelerate a global shift from reactive sick care to proactive, preventive health care. We work at the forefront of science and technology and we believe a collaborative approach to modern medicine can extend healthy life for all.

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