Does adenosine infusion induce migraine attacks in migraine patients?

Описание: Adenosine is a purinergic signaling molecule with a wide range of physiological functions. Studies have shown that adenosine infusions can induce headache, and adenosine receptor antagonist, caffeine, relieves migraine headache. Janu Thuraiaiyah, MD, PhD, Danish Headache Center, University of Copenhagen, Glostrup, Denmark, discusses the findings of a randomized, double-blinded, placebo-controlled, crossover study assessing the difference in the incidence of migraine attacks after adenosine compared to placebo. A total of 18 participants diagnosed with migraine without aura received an infusion of adenosine or placebo over 20 minutes. Headache intensity, migraine-associated symptoms, vital signs, the diameter of the superficial temporal artery (STA), and blood flow velocity in the middle cerebral artery (VMCA) were measured at baseline and every 10 minutes until two hours post-infusion start. Results showed no difference in the incidence of migraine following adenosine compared to placebo, but the incidence of headache after adenosine compared to placebo was statistically significant. Additionally, adenosine increased STA diameter and decreased VMCA compared to placebo. Together those findings suggest that adenosine causes short-lasting vasodilation and headache, but not migraine attacks in migraine patients. This interview took place at the 16th European Headache Congress (EHC) in Vienna, Austria.

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