RFRF Grant Recipient Interview: Allison Bradbury, MS, PhD

Описание: An interview with RFRF grant recipient Allison Bradbury about her grant work studying Krabbe disease dog models, her experiences getting research funding, and more.

Allison M. Bradbury, MS, PhD is a tenure track assistant professor in the Department of Pediatrics at The Ohio State University and Principal Investigator in the Center for Gene Therapy at Nationwide Children’s Hospital. She leads a R01-funded translational laboratory with the goal of improving the understanding of disease mechanisms resulting in rare pediatric neurologic disorders to develop safe and efficacious targeted gene therapy approaches.

Dr. Bradbury received her PhD in Biomedical Sciences from Auburn University (2009-2014) where her doctoral research was focused on the development of AAV gene therapy in a feline model of GM2 gangliosidosis. This therapy is now in human clinical trials. Successively, her postdoctoral research fellowship was completed at the University of Pennsylvania and supported by a NRSA F32 Fellowship and NIH K99/R00 Pathway to Independence grant. During her postdoctoral fellowship she conducted a comprehensive natural history study in the canine model of globoid cell leukodystrophy (Krabbe disease) and demonstrated therapeutic efficacy in this model for the first time by utilizing AAV gene therapy to target both central and peripheral nervous system disease, with successful translation to the clinic. In her independent laboratory, Dr. Bradbury continues to optimize and translate next generation gene therapies for Krabbe disease.

Learn more at https://rosenaufoundation.org/bradbury-2024/