IL-11, Trametinib & Rapamycin = Impressive Lifespan Effects? We Take a Look.

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Check out paper #1 on IL-11 signaling: https://www.nature.com/articles/s4158...

Check out paper #2 on combination trametinib/rapamycin treatment: https://www.biorxiv.org/content/biorx...

Related episodes:

An introduction to the study of RAPAMYCIN:    • An introduction to the study of RAPAMYCIN ...  

In this episode, Matt discusses two recent mouse lifespan studies: one focused on inhibiting IL-11 signaling, and one focused on combined trametinib and rapamycin treatment. IL-11, or Interleukin-11, is a protein that plays an important role in modulating inflammation and healing, while trametinib is an FDA-approved drug that targets certain cancers, particularly melanoma. You can find extensive discussion of rapamycin in our R-Files series linked above. Matt explains the "900-day rule" for evaluating mouse lifespan studies such as these two, and provides his take on whether these results are game-changers for the geroscience field as well as whether we should consider these interventions for human use at this time.

0:00 Introduction
2:22 The 900-day rule
4:35 Applying the rule in practice: the IL-11 paper
7:48 Comparing the result to that of other lifespan experiments
10:55 Applying the rule in practice: trametinib/rapamycin combination treatment
15:47 Takeaways

Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa

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https://www.optispan.life/

Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!