Stronger, Leaner, Sharper: Meet SLU-PP-332

Описание: What if you could mimic the effects of exercise at the cellular level—without hours in the gym? In this episode of The Dr. Jones Optimization Podcast, Dr. Greg Jones sits down with Anthony Castore, founder of DRIVE Longevity Solutions and Fellow of the SSRP Institute, to break down the science and strategy behind SLU-PP-332, an exercise mimetic compound with powerful mitochondrial and metabolic benefits.

Together, they explore how SLU-PP-332 works through the PGC1α–AMPK–ERR axis, activating mitochondrial biogenesis, boosting metabolic flexibility, and enhancing fat oxidation—even in a parasympathetic state. Anthony explains why this compound is generating excitement among performance coaches, biohackers, and clinicians: it improves recovery, VO₂ max, endurance, organ health, and body composition while supporting neuroprotection and longevity.

Key topics include ERR receptors, fat-loss synergy with fasting and cold plunges, personalized dosing strategies, gender-based differences, and how to balance AMPK and mTOR for both performance and long-term health. Anthony also shares real-world results from elite athletes and patients, plus his framework for measuring success with markers like RER, Lumen, fasting glucose, and HRV.

If you’re a clinician, athlete, or health optimizer curious about cutting-edge cellular medicine, this deep dive into SLU-PP-332 offers evidence-informed insights and practical applications.

📌 About Anthony Castore
Founder of DRIVE Longevity Solutions | SSRP Fellow | National performance and cellular medicine coach
Instagram: @anthonycastore

🎙️ Connect with Dr. Greg Jones
Instagram: @doctorjones_doctorjones
Become a patient: https://enovativewellness.com/

💡 This episode is brought to you by Tides Health — Code DRJONES for 15% off: https://yourtides.com/

🔗 Want to learn more? Check out these resources:
NIH – Mitochondria and Energy Metabolism: https://www.ncbi.nlm.nih.gov/books/NB...
Harvard Health – Exercise and Cellular Health: https://www.health.harvard.edu/
PubMed – PGC-1α and Mitochondrial Biogenesis: https://pubmed.ncbi.nlm.nih.gov/18487...

🔬 Timestamps
00:00 – Meet Anthony Castore: Longevity & performance coaching
10:30 – ERR receptors and non-ligand activation explained
17:08 – SLU-PP-332 as a mitochondrial enhancer
19:37 – PGC1α–AMPK–ERRα axis: the exercise mimetic pathway
24:47 – Exercise mimetic vs exercise replacement
25:12 – Synergy with fasting, HIIT & cold plunges
30:49 – Real-world results: VO₂, recovery, body comp
34:23 – Muscle retention & metabolic flexibility
35:42 – Fat loss in parasympathetic state
36:32 – Timing SLU-PP-332: morning & post-workout
38:31 – Organ health: liver, kidney, A1C improvements
42:45 – Dosing protocols & titration strategies
43:15 – Measuring metabolic flexibility: RER, Lumen, glucose
47:16 – Men vs women: dosing differences
48:14 – Mitochondrial support stack (CoQ10, NAD, NAC, SS-31)
50:22 – Redox balance & when to back off
53:40 – Side effects & estrogen dominance risk
56:28 – Smart protocols vs reckless stacking
56:50 – Learning more: mechanisms over marketing
59:01 – Final advice: curiosity vs. intensity
01:00:34 – Outro & where to find Anthony

#SLUPP332 #Mitochondria #ExerciseMimetic #Longevity #FatLoss #Performance

Disclaimer: The information shared on The Dr. Jones Optimization Podcast and its associated YouTube channel is intended for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Listening to this podcast or viewing its content does not create a doctor–patient relationship, and nothing shared should be interpreted as individualized medical guidance. Always consult with a qualified healthcare provider before making changes to your health regimen or managing a medical condition. The opinions expressed by Dr. Jones and his guests are their own and do not reflect official medical advice or recommendations.