Searching for the ideal CAR-T target in AML: balancing expression and toxicity
Автор: VJHemOnc – Video Journal of Hematology & HemOnc
Загружено: 2026-02-16
Просмотров: 25
Описание:
Florian Van Oers, MD, University of Antwerp, Antwerp, Belgium, discusses the challenges of balancing expression and toxicity when searching for novel CAR T-cell therapy targets in acute myeloid leukemia (AML), highlighting the need for an ideal target that combines broad expression with minimal toxicity. Dr Van Oers notes that targets such as CD33 and CD123 have been widely explored but lead to significant toxicity due to their expression on normal hematopoietic stem cells, whereas ADGRE2 (adhesion G protein-coupled receptor E2) emerges as a promising candidate due to its high expression on leukemic stem cells, while sparing normal hematopoietic cells, T-cells, and neutrophils. This interview took place at the EBMT-EHA 8th European CAR T-cell Meeting, held in Palma de Mallorca, Spain.
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