Geoff Chong, MD, Shares Data on Novel Bispecific Antibody in Follicular Lymphoma
Автор: Blood Cancers Today
Загружено: 2024-05-07
Просмотров: 211
Описание:
Dr. Chong, an Associate Professor at the Olivia Newton-John Cancer Centre, discusses his research presented at the American Association for Cancer Research Annual Meeting 2024.
The ELM-2 trial studied odronextamab, a CD20×CD3 bispecific antibody, in patients with relapsed or refractory follicular lymphoma. The objective response rate was 80.5%, the complete response rate was 73.4%, and the median progression-free survival was 20.7 months.
Dr. Chong described the safety as “generally manageable.” About half (56.7%) of patients experienced grade 1 cytokine release syndrome (CRS), 45% had grade 2 CRS, and 10% had grade 3 CRS. Infection occurred in about 80% of patients.
“There are high response and complete response rates in the relapsed or refractory population,” Dr. Chong said. “We’re certainly on to a good treatment for the future, and this trial provides a good setting for further investigation of odronextamab.”
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