Partition coefficient of benzoic acid in water and benzene
Автор: Chemistry: The Way of Life
Загружено: 2026-03-03
Просмотров: 42
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A partition coefficient is the ratio of a chemical's equilibrium concentrations between two immiscible solvents (commonly n-octanol and water), measuring its lipophilicity. It indicates if a substance prefers hydrophobic (oil) or hydrophilic (water) phases, crucial for assessing drug absorption, environmental fate, and passive diffusion.
Influence of pH: The partition coefficient is higher in acidic media (at pH 4.0) compared to neutral (at pH 7.0) or basic media (at pH 9.0).
Method: It is determined by shaking benzoic acid in a benzene-water mixture, allowing phases to separate, and titrating.
Important Considerations
Dimerization: Benzoic acid dimerizes in benzene, which affects the distribution, often requiring a log-log plot to find the true constant.
Temperature: Experiments are typically performed at room temperature, and results can vary slightly based on the exact temperature
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