GLP-1 Receptor Agonists and Psychiatric Disorders: Evidence From a Systematic Review Fifty 410

Описание: A new systematic review examined the effects of GLP-1 receptor agonists on a range of psychiatric and neurological conditions, including depression, anxiety, bipolar disorder, substance use disorders, Parkinson’s disease, and Alzheimer’s disease.

This review analyzed existing preclinical and human studies and found signals suggesting GLP-1 medications may influence cognitive, behavioral, and mood-related outcomes, likely through effects on brain metabolism, inflammation, and reward pathways. Importantly, the review did not find evidence of worsening psychiatric outcomes across the conditions studied.

It is critical to be clear about scope and limitations:
GLP-1 medications are not approved treatments for psychiatric disorders
The evidence base is still evolving

Many findings are preliminary and require larger, long-term randomized clinical trials

This video explains what the research actually shows, what it does not show, and why scientists in neurology and psychiatry are increasingly interested in the brain-metabolism connection.

This content is for educational purposes only and does not provide medical advice. Medication decisions should always be made in consultation with a qualified healthcare provider.

Source:
Effects of glucagon-like peptide-1 receptor agonists on psychiatric disorders: a systematic review
Therapeutic Advances in Psychopharmacology (2025)

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