Which Works Better—Hydrocortisone or Prednisone?

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Hydrocortisone and prednisone are both corticosteroids that replace cortisol in conditions like adrenal insufficiency—but they work in different ways. This video compares their potency, dosing schedules, and side effect profiles, and explains why one might be preferred over the other. You’ll learn about innovative treatment options, including continuous hydrocortisone infusion and custom-compounded doses, that can help mimic the body’s natural cortisol rhythms. The goal: help you understand your choices so you can work with your healthcare provider to find the most effective and tolerable treatment plan.

Key Takeaways:
1. Potency Difference: 5 mg prednisone ≈ 20 mg hydrocortisone. Prednisone is more potent and lasts longer, while hydrocortisone requires higher and more frequent doses.
2. Common Uses: Prednisone is more common in the U.S. for its once-daily convenience. Hydrocortisone is standard for adrenal insufficiency and Addison’s disease.
3. Side Effect Profiles: Prednisone’s longer action can cause insomnia. Hydrocortisone may lead to fluctuating hormone levels and variable symptoms.
4. Advanced Options: Continuous subcutaneous hydrocortisone infusion and sustained-release formulations from compounding pharmacies can better mimic natural cortisol cycles.
5. Tailored Treatment: The right choice depends on potency needs, dosing preference, side effect tolerance, and the specific condition being treated.

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Dr. Megan is the Prednisone Pharmacist who experienced side effects from a prescription drug called prednisone. Here she teaches tips to deal with side effects naturally. Every week Dr. Megan posts a new video with an answer to your burning prednisone questions.

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