Harnessing Ligand Kinetics for Predicting GPCR Therapeutic Effects |

Описание: Getting accurate predictions of in vivo efficacy requires more than looking at affinity or potency. The real-world outcomes in GPCR drug discovery often hinge on ligand binding and unbinding rates—factors that reshape how we interpret both functional and binding assay data.

This session puts kinetic rate constants front and center, showing how to derive kon and koff and apply these values to real experimental situations. You’ll dig into recognizing kinetic pitfalls, clarifying therapeutic coverage, and connecting kinetic parameters to meaningful pharmacodynamic effects. Hands-on examples highlight what you might miss by ignoring kinetics.

Dr. Terry Kenakin walks through core concepts and demonstrates how kinetic analysis directly impacts interpretation and prediction in your own GPCR research. The discussion is concrete and grounded in practical challenges facing scientists in drug development.

Learning Outcomes
Interpret functional and binding assay data using ligand kinetic parameters
Identify kinetic pitfalls that affect drug action and efficacy
Apply kon and koff to predict therapeutic outcomes and pharmacodynamic profiles

Dr. GPCR Mission
Dr. GPCR is a scientist-led nonprofit focused on advancing GPCR science through rigor, education, and collaboration.
Dr. GPCR University builds on this mission by providing a shared learning environment for the global GPCR community, supporting open exchange and scientific progress.

Unlock full access to all Masterclasses and Premium resources:
👉 https://www.ecosystem.drgpcr.com/gpcr...

🧠 Want more like this?

Join the Dr. GPCR Premium Ecosystem to unlock exclusive episodes, practical toolkits, and early access to GPCR University content.

👉 https://www.ecosystem.drgpcr.com/gpcr...

_____

Join Terry’s Corner today!

Visit https://www.terrykenakin.com for expert-led, on-demand pharmacology courses, and join us at the monthly AMAs with Dr. Terry Kenakin.

https://www.ecosystem.drgpcr.com/terr...
_____

Get to know our Partner:

👉 Celtarys Research

• Company Page: https://www.ecosystem.drgpcr.com/celt...
• Press Release: https://www.ecosystem.drgpcr.com/post...
• Celtarys News: https://www.ecosystem.drgpcr.com/gpcr...

Dr. GPCR is dedicated to fostering a collaborative ecosystem focused on GPCRs. By connecting researchers, sharing knowledge, and facilitating partnerships, the #DrGPCR Ecosystem provides resources to advance GPCR drug discovery.

The ecosystem encompasses a range of initiatives to inform and engage the scientific community, including courses, news updates, and networking opportunities.